October 30, 2003

Beeswax

Sridhar Ramaswamy was just down for a visit and gave a very nice presentation of his work. Over dinner and in his talk the following day, he's taken the view that immediate clinical applicability and pure scientific curiousity are at odds when it comes genomics.

Essentially, he suggests, the key is to reconcile long-term outcome with gene expression patterns, and this is only possible with formalin-fixed tissues in paraffin blocks because adequately prepared fresh frozen tissue samples are too "young" to yield us long-term follow-up data. Therefore, understanding that paraffin blocks will yield far few gene expression signals, why not identify representative genes that lie near the centroids of broader signatures and RT-PCR these signals out of tissue blocks?

This is a compelling argument, and I'd have to counter this way:
1. Broadly, to really understand cancer requires basic science moving hand-in-hand with clinical insight; and this can only happen with frozen tissues and microarray analysis.

2. More specifically, the key difference between what our group is doing and what other groups are doing is not to stop at one classification, but to keep on going, and whittling the complex pathophysiologic phenomenon of cancer down to the individual. Keep on subdividing your data until you can't divide any further, and what you have left is the individual patient with all the idiosyncratic characteristics of her disease. You can't do this with 70 genes. You might be able to make the first cut, but the information peters out after this.

3. Banking frozen tissue, and more importantly, banking all the information you cull from it is an investment for the future. There is little chance that your initial analytic approaches will properly mine all the ore out of your data. Why go through the trouble of creating massively multivariate data and throw away most of it?

Posted by erich at October 30, 2003 08:31 PM | TrackBack
Comments

I have found the best online store to

order Generic Viagra
Buy Generic Cialis
Buy Generic Lipitor

Posted by: Buy Generic Viagra at July 14, 2004 12:38 AM

Buy Viagra online.

Viagra prescription

Posted by: Viagra online at July 16, 2004 09:29 PM

I have found the best online pharmacy for buying
Ambien
Sonata

Posted by: Buy Ambien at July 27, 2004 02:06 PM

Yours is a great site. I want to share with you that I have found the best online
pharmacy to

order Ambien and
order Sonata

Posted by: Ambien at August 3, 2004 03:59 PM

Viagra, Cialis and Levitra prescription from online pharmacy:

Viagra online
Levitra online
Cialis online

Posted by: Viagra cheap at August 14, 2004 08:34 AM

Viagra, Cialis and Levitra prescription from online pharmacy:

Viagra online
Levitra online
Cialis online

Posted by: Viagra cheap at August 14, 2004 12:17 PM

Viagra, Cialis and Levitra prescription from online pharmacy:

Viagra online
Levitra online
Cialis online

Posted by: Viagra cheap at August 14, 2004 04:01 PM

I have found the best site to:

order Viagra
order Levitra
order Cialis

Posted by: cheap Viagra at August 14, 2004 06:24 PM

I have found the best site to:

order Viagra
order Levitra
order Cialis

Posted by: cheap Viagra at August 15, 2004 12:19 AM

Yours is a great site.

I have the best online store to buy Cialis

Posted by: Buy Cialis at August 29, 2004 11:13 AM

Yours is a great site.

I have the best online store to buy Cialis

Posted by: Buy Cialis at August 29, 2004 02:51 PM

Yours is a great site.

I have the best online store to buy Cialis

Posted by: Buy Cialis at August 29, 2004 06:28 PM

Thanks for a great site.

I have the best online store to buy Cialis

Posted by: Buy Cialis at August 30, 2004 10:15 AM

Thanks for a great site.

I have the best online store to buy Cialis

Posted by: Buy Cialis at August 30, 2004 04:05 PM

you will never have to even think about it in the future.

Posted by: penimaster at September 2, 2004 02:45 PM

Jes extender will change your life. you will never have to even think about it in the future.

Posted by: Jes extender at September 3, 2004 05:44 PM

Nice site also visit Tramadol site.

Posted by: Tramadol at September 12, 2004 09:15 AM

Nice site also visit Tramadol site.

Posted by: Tramadol at September 12, 2004 12:00 PM

Nice site also visit Tramadol site.

Posted by: Tramadol at September 12, 2004 02:54 PM

Nice site also visit Tramadol site.

Posted by: Tramadol at September 12, 2004 04:06 PM

Nice site also visit Tramadol site.

Posted by: Tramadol at September 12, 2004 08:28 PM

Zithromax online antibiotic.

Posted by: Zithromax Online at September 23, 2004 05:08 AM

Zithromax online antibiotic.

Posted by: Zithromax Online at September 23, 2004 08:44 AM

Zithromax online antibiotic.

Posted by: Zithromax Online at September 23, 2004 12:12 PM

Zithromax online antibiotic.

Posted by: Zithromax Online at September 24, 2004 03:33 AM

Zithromax online antibiotic.

Posted by: Zithromax Online at September 24, 2004 08:16 AM

Amoxicillin information.

Posted by: Amoxicillin at October 4, 2004 05:01 AM

Amoxicillin information.

Posted by: Amoxicillin at October 4, 2004 08:23 AM

Information on Amoxicillin

Posted by: Amoxicillin at October 4, 2004 09:18 AM

Amoxicillin information.

Posted by: Amoxicillin at October 4, 2004 11:39 AM

Information on Amoxicillin

Posted by: Amoxicillin at October 4, 2004 02:31 PM

Cialis information site.

Posted by: Cialis at October 8, 2004 01:47 PM

Cialis information site.

Posted by: Cialis at October 8, 2004 02:20 PM

A bad cause will ever be supported by bad means and bad men.

Posted by: free online poker at October 8, 2004 03:56 PM

Cialis information site.

Posted by: Cialis at October 8, 2004 05:24 PM

Cialis information site.

Posted by: Cialis at October 8, 2004 07:05 PM

Cialis information site.

Posted by: Cialis at October 8, 2004 08:13 PM

There is no great genius without some touch of madness.

Posted by: texas holdem at October 9, 2004 06:44 AM

Man is a social animal.

Posted by: texas holdem rule at October 9, 2004 08:29 PM

Time heals what reason cannot.

Posted by: free online poker at October 9, 2004 11:57 PM

Hegel says somewhere that all great events and personalities in world history reappear in one fashion or another. He forgot to add: the first time as tragedy, the second as farce.

Posted by: best casino online at October 10, 2004 04:08 AM

Why, then, do you walk as if you had swallowed a ramrod?

Posted by: poker online at October 10, 2004 07:53 AM

All men are liable to error; and most men are, in many points, by passion or interest, under temptation to it.

Posted by: free poker online at October 10, 2004 11:33 AM

If you talk to God, you are praying; if God talks to you, you have schizophrenia.

Posted by: online poker at October 10, 2004 04:58 PM

If it be a short and violent death, we have no leisure to fear it; if otherwise, I perceive that according as I engage myself in sickness, I do naturally fall into some disdain and contempt of life.

Posted by: poker online at October 11, 2004 04:56 AM

Buying books would be a good thing if one could also buy the time to read them in: but as a rule the purchase of books is mistaken for the appropriation of their contents.

Posted by: online poker at October 11, 2004 07:14 PM

Every great advance in science has issued from a new audacity of imagination.

Posted by: texas holdem poker at October 12, 2004 03:56 AM

Aristotle maintained that women have fewer teeth than men; although he was twice married, it never occurred to him to verify this statement by examining his wives' mouths.

Posted by: free online poker at October 12, 2004 11:21 AM

Info on Levaquin online.

Posted by: Levaquin at October 12, 2004 01:59 PM

Info on Levaquin online.

Posted by: Levaquin at October 12, 2004 02:07 PM

Info on Levaquin online.

Posted by: Levaquin at October 12, 2004 05:23 PM

Info on Levaquin online.

Posted by: Levaquin at October 12, 2004 06:56 PM

For words are wise men's counters, they do but reckon with them; but they are the money of fools.

Posted by: free online poker at October 12, 2004 08:15 PM

Info on Levaquin online.

Posted by: Levaquin at October 12, 2004 08:18 PM

Every law is an evil, for every law is an infraction of liberty.

Posted by: online poker at October 13, 2004 02:08 AM

It is only our bad temper that we put down to being tired or worried or hungry; we put our good temper down to ourselves.

Posted by: free online poker at October 13, 2004 08:24 AM

Consciousness is a word worn smooth by a million tongues.

Posted by: free poker online at October 14, 2004 03:02 AM

Seasonale online site.

Posted by: Seasonale at October 14, 2004 08:28 AM

Seasonale online site.

Posted by: Seasonale at October 14, 2004 08:41 AM

I think that philosophy in most aspects is pretty well useless and hopeless unless it's done with other disciplines. And that's the way I like to do it.

Posted by: poker online at October 14, 2004 09:22 AM

Seasonale online site.

Posted by: Seasonale at October 14, 2004 12:01 PM

Seasonale online site.

Posted by: Seasonale at October 14, 2004 01:57 PM

Seasonale online site.

Posted by: Seasonale at October 14, 2004 03:12 PM

The nationalist not only does not disapprove of atrocities committed by his own side, but he has a remarkable capacity for not even hearing about them.

Posted by: texas holdem tips at October 14, 2004 04:51 PM

Education is not preparation for life; education is life itself.

Posted by: online texas holdem at October 14, 2004 09:50 PM

Man is condemned to be free.

Posted by: online poker at October 15, 2004 02:45 AM

Generic Fioricet online site.

Posted by: Generic Fioricet online at October 15, 2004 10:35 AM

Generic Fioricet online site.

Posted by: Generic Fioricet at October 15, 2004 10:45 AM

Generic Fioricet online site.

Posted by: Generic Fioricet at October 15, 2004 02:08 PM

Generic Fioricet online site.

Posted by: Generic Fioricet online at October 15, 2004 03:54 PM

Generic Fioricet online site.

Posted by: Generic Fioricet at October 15, 2004 05:09 PM

Beeswax candles are beautiful, fragrant and very easy to make. They do not drip or smoke and burn longer, with a warmer glow, than paraffin candles. With a little help from an adult, even very young children get great results, making this a perfect activity for the entire family.Beeswax has a naturally tacky surface, so you can decorate candles with beads, sequins, shells or other shapes cut out of colored wax, simply by pressing the decorations gently onto the candle. They make very elegant gifts when left plain and tied in a pair or bundle with raffia or fancy ribbon.


Posted by: phentermine 37.5 mg at October 17, 2004 11:57 PM

Fioricet prescription info site.

Posted by: Fioricet at October 18, 2004 03:43 AM

Fioricet prescription info site.

Posted by: Fioricet at October 18, 2004 03:47 AM

Fioricet prescription info site.

Posted by: Fioricet at October 18, 2004 06:56 AM

Fioricet prescription info site.

Posted by: Fioricet at October 18, 2004 08:17 AM

Fioricet prescription info site.

Posted by: Fioricet at October 18, 2004 09:54 AM

Prozac online info site.

Posted by: Prozac at October 19, 2004 02:48 AM

Prozac online info site.

Posted by: Prozac at October 19, 2004 02:55 AM

Prozac online info site.

Posted by: Prozac at October 19, 2004 05:44 AM

Prozac online info site.

Posted by: Prozac at October 19, 2004 07:18 AM

Prozac online info site.

Posted by: Prozac at October 19, 2004 08:28 AM

Online Ionamin information.

Posted by: Ionamin at October 20, 2004 07:58 AM

Online Ionamin information.

Posted by: Ionamin at October 20, 2004 10:44 AM

Online Ionamin information.

Posted by: Ionamin at October 20, 2004 01:37 PM

The action is best, which procures the greatest happiness for the greatest numbers.

Posted by: online casino at October 21, 2004 03:00 AM

The total absence of humour from the Bible is one of the most singular things in all literature.

Posted by: free online casino at October 21, 2004 09:48 AM

Remeron information.

Posted by: Remeron at October 22, 2004 11:51 AM

Remeron information.

Posted by: Remeron online at October 22, 2004 12:03 PM

Remeron information.

Posted by: Cheap Remeron at October 22, 2004 03:08 PM

Remeron information.

Posted by: Remeron at October 22, 2004 04:46 PM

Remeron information.

Posted by: Cheap Remeron at October 22, 2004 06:07 PM

Brand New Pocket Bike Latest 2005 Models are here!
New arrivals!

Posted by: pocket bikes at October 23, 2004 09:08 AM

Brand New Pocket Bike Latest 2005 Models are here!
New arrivals!

Posted by: pocket bike at October 23, 2004 12:02 PM

For Effexor information.

Posted by: cheap Effexor at October 23, 2004 02:38 PM

Penis enlargement - Feel a bit interested? Read more revealing columns!

Posted by: penis enlargement at October 23, 2004 02:42 PM

Effexor online information site.

Posted by: cheap Effexor at October 23, 2004 02:49 PM

Effexor online information site.

Posted by: Effexor cheap at October 23, 2004 05:47 PM

For Effexor information.

Posted by: Effexor online at October 23, 2004 07:23 PM

Effexor online information site.

Posted by: Effexor cheap at October 23, 2004 08:35 PM

Medx DIRECT offers a quick reliable solution for those needs we all must have met. Our three products(xanax,Valium,Codeine) are the most popular and safe means of every-day life solvers.

Posted by: xanax at October 23, 2004 09:39 PM
Post a comment









Remember personal info?